About Journal of Colon and Rectal Cancer
Advancing molecular understanding of colorectal cancer through rigorous, peer-reviewed research focused on disease mechanisms, biomarkers, and pathophysiology
Mechanistic Focus
Publishing research that elucidates cellular pathways, genetic alterations, and molecular mechanisms driving colorectal cancer initiation, progression, and metastasis.
Biomarker Discovery
Advancing identification and validation of diagnostic, prognostic, and predictive biomarkers through genomic, proteomic, and metabolomic investigations.
Translational Bridge
Connecting laboratory discoveries to potential clinical applications by highlighting mechanistic insights that inform therapeutic target development.
JCRC welcomes original research articles, comprehensive reviews, and methodological papers that advance our molecular understanding of colorectal cancer. Our scope encompasses diverse aspects of disease pathophysiology while maintaining strict focus on mechanisms rather than clinical practice.
Oncogene activation, tumor suppressor inactivation, microsatellite instability, chromosomal instability, DNA methylation patterns, and chromatin remodeling mechanisms.
Wnt/?-catenin, MAPK/ERK, PI3K/AKT, TGF-?, Notch, and Hedgehog pathway alterations in colorectal tumorigenesis and progression.
Cancer-associated fibroblasts, immune cell infiltration, extracellular matrix remodeling, hypoxia signaling, and metabolic reprogramming within the tumor ecosystem.
Discovery and validation of circulating tumor DNA, protein markers, metabolic signatures, exosomal cargo, and multi-omics panels for disease detection and monitoring.
Epithelial-mesenchymal transition, invasion biology, angiogenesis, lymphangiogenesis, organ-specific metastatic tropism, and pre-metastatic niche formation.
Identification, characterization, and functional analysis of colorectal cancer stem cell populations, self-renewal mechanisms, and differentiation pathways.
Consensus molecular subtyping, transcriptomic classification systems, proteomic profiling, and integrative multi-platform characterization approaches.
Development and validation of cell lines, organoid systems, patient-derived xenografts, genetically engineered mouse models, and in vitro/in vivo platforms.
Histopathological correlates of molecular alterations, spatial omics, tissue-based biomarker analysis, and pathophysiological classification systems.
JCRC publishes diverse article types to accommodate the breadth of colorectal cancer research while maintaining rigorous standards for mechanistic insight and scientific rigor.
- Original Research Articles: Comprehensive reports of novel mechanistic findings, biomarker discovery studies, or methodological advances in colorectal cancer research
- Review Articles: Systematic or narrative reviews synthesizing current understanding of specific molecular mechanisms, pathways, or biomarker landscapes
- Methodology Articles: Detailed descriptions of innovative experimental approaches, analytical techniques, or model systems for studying colorectal cancer biology
- Short Communications: Rapid dissemination of significant preliminary findings, novel observations, or technical innovations
- Systematic Reviews: Meta-analyses and systematic evidence synthesis focused on molecular mechanisms or biomarker performance
- Hypotheses: Well-reasoned theoretical frameworks proposing novel mechanistic concepts or unexplored research directions
- Data Reports: Comprehensive datasets from genomic, transcriptomic, proteomic, or metabolomic studies with detailed annotation
Rigorous Single-Blind Review: Every submission undergoes evaluation by at least two independent experts in molecular oncology, cancer biology, or relevant specialized fields. Reviewers assess mechanistic rigor, experimental design, analytical validity, reproducibility, and significance of findings. Authors receive constructive feedback regardless of publication decision.
Initial Screening
Editorial team evaluates scope alignment, focusing on mechanistic content rather than clinical application. Manuscripts emphasizing patient management or therapeutic protocols are redirected to appropriate clinical journals.
Expert Review Assignment
Manuscripts are assigned to reviewers with expertise in relevant molecular pathways, experimental systems, or analytical methodologies. Reviewers assess mechanistic insights, methodological rigor, and reproducibility.
Author Revision
Authors receive detailed feedback addressing experimental design, data interpretation, mechanistic conclusions, and presentation clarity. Point-by-point responses to reviewer comments are required.
Final Decision and Publication
Revised manuscripts undergo final editorial evaluation. Accepted articles are professionally copyedited, proofread, and published online with immediate open-access availability.
Authors submitting to JCRC should carefully review our Instructions for Authors to ensure manuscripts align with our mechanistic focus. Key requirements include:
Clear articulation of molecular mechanisms, cellular pathways, or disease processes investigated
Detailed methods, appropriate controls, statistical analysis, and reproducibility considerations
Raw data availability, reagent specifications, and adherence to reporting guidelines (ARRIVE, MIQE, etc.)
Institutional approval for human biospecimen studies, IACUC protocols for animal research, conflict of interest disclosure
Scope Clarity: JCRC focuses exclusively on disease mechanisms and molecular pathophysiology. Manuscripts primarily addressing clinical outcomes, therapeutic efficacy, patient management protocols, or healthcare delivery fall outside our scope. Authors should emphasize mechanistic insights, biomarker discovery, or fundamental disease biology rather than clinical applications.
Expert Editorial Oversight
JCRC's editorial operations are guided by an international Editorial Board comprising distinguished researchers in molecular oncology, cancer genetics, tumor biology, and translational research. Board members provide strategic direction, evaluate manuscripts in their areas of expertise, and ensure published research meets the highest standards of scientific rigor.
Our editors bring diverse methodological expertise spanning genomics, proteomics, systems biology, animal models, organoid technology, and computational approaches, ensuring comprehensive evaluation of mechanistic research across all colorectal cancer biology domains.
JCRC operates as a fully open-access journal, removing barriers to knowledge dissemination and maximizing research impact. Published articles are immediately available worldwide without subscription fees, enabling researchers in resource-limited settings to access cutting-edge molecular cancer research.
Copyright and Licensing: Authors retain copyright under Creative Commons Attribution 4.0 International (CC BY 4.0) license, permitting unrestricted use, distribution, and reproduction with appropriate attribution. This facilitates knowledge translation, educational use, and integration into systematic reviews and meta-analyses.
JCRC content is indexed in major bibliographic databases and discovery services, ensuring maximum visibility within the research community. Our articles are discoverable through Google Scholar, ResearchGate, academic institutional repositories, and specialized oncology research platforms.
Contribute to Colorectal Cancer Research
Join our global community of researchers advancing molecular understanding of colorectal cancer. Submit your mechanistic discoveries, biomarker studies, and translational research to JCRC and benefit from rigorous peer review, rapid publication, and open-access dissemination.
Contact Information: For inquiries about manuscript suitability, editorial policies, or submission procedures, contact the JCRC editorial office at [email protected]. Our team is committed to providing responsive, professional support throughout the publication process.
